Multi-omics Characterization and Model Construction of Colchicine Anti-inflammatory Therap
The aim of this prospective cohort study was to investigate the multi-omics characteristics of the efficacy of colchicine treatment in patients with ACS and to construct a model of efficacy. The main questions the study aims to answer are \- Specific mechanisms of colchicine therapy in patients with ACS; Mechanism-base
| Condition(s) | ACS - Acute Coronary Syndrome |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The aim of this prospective cohort study was to investigate the multi-omics characteristics of the efficacy of colchicine treatment in patients with ACS and to construct a model of efficacy. The main questions the study aims to answer are \- Specific mechanisms of colchicine therapy in patients with ACS; Mechanism-based modelling to identify the population that benefits from colchicine treatment. |
| Who can participate | Inclusion Criteria: * Between the ages of 18 and 80 * ACS (STEMI or NSTE-ACS) * Patients to receive standardised drug therapy * Able and willing to provide informed consent Exclusion Criteria: * Any contraindication to colchicine or known intolerance to colchicine * Has been using colchicine for a prolonged period of time for other medical conditions * Women of childbearing age who are pregnant, breastfeeding or not using effective contraception * Coronary artery bypass grafting within the last 3 years or planned * Severe hepatic impairment: elevated serum alanine aminotransferase and/or aminotransferase (ALT) and/or aminotransferase (AST) levels of up to three times the upper limit of normal * Severe renal impairment: eGFR \<30mL/min/1.73m2 * Thrombocytopenia (platelet count less than 100 |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Lead sponsor | Shanghai Tongji Hospital, Tongji University School of Medicine |
| Locations | Shanghai, China |
| Start date | 2025-07-01 |
| NCT ID | NCT07064109 |
| Official listing | https://clinicaltrials.gov/study/NCT07064109 |