Multimodal Prognostic Assessment of Acute Ischemic Stroke Patients With Atrial Fibrillatio
The main purpose of this study is to investigate the safety and outcomes of different treatment strategies, including best medical therapy (OAC \[oral anticoagulation\], antiplatelet \[APT\]) and left atrial appendage closure \[LAAC\] in acute ischemic stroke (AIS) patients with atrial fibrillation (AF) based on multim
| Condition(s) | Acute Ischemic Stroke, Atrial Fibrillation |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The main purpose of this study is to investigate the safety and outcomes of different treatment strategies, including best medical therapy (OAC \[oral anticoagulation\], antiplatelet \[APT\]) and left atrial appendage closure \[LAAC\] in acute ischemic stroke (AIS) patients with atrial fibrillation (AF) based on multimodal assessment from combined brain and cardiologic work-up, and to optimize secondary prevention. |
| Who can participate | Inclusion Criteria: 1. Age \> 18 years old； 2. Acute ischemic stroke with onset ≤ 14 days； 3. Previously or during this hospitalization diagnosed with non-valvular atrial fibrillation; 4. Informed consent obtained from the patient or his/her legal representative； Exclusion Criteria: 1. Pacemaker, implantable cardioverter defibrillator or implantable cardiac monitor; 2. Left atrial appendage has been removed or post occlusion device implantation; 3. Transient AF secondary to other reversible disorders； 4. Life expectancy less than 1 year; 5. Patients that cannot complete subsequent follow-up (e.g. no fixed residence, overseas patients, etc.); 6. Females who are pregnant or in lactation; 7. Participating in other clinical trials that could confound the evaluation of the study; 8. Other circu |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Jinan Central Hospital |
| Locations | Jinan, Shandong, China |
| Start date | 2024-11-15 |
| NCT ID | NCT06548269 |
| Official listing | https://clinicaltrials.gov/study/NCT06548269 |