Neural Control of Breathing in Parkinson's Disease
Breathing is a complex process, which can be controlled through voluntary command or neural control. Parkinson's disease (PD) is a progressive neurological disorder. Many individuals with PD experience respiratory problems, such as coughing difficulties or shortness of breath. Changes in neural control of breathing cou
| Condition(s) | Parkinson Disease |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Breathing is a complex process, which can be controlled through voluntary command or neural control. Parkinson's disease (PD) is a progressive neurological disorder. Many individuals with PD experience respiratory problems, such as coughing difficulties or shortness of breath. Changes in neural control of breathing could be part of the reason of these respiratory problems. This study will measure whether neural control of breathing is impaired in individuals with PD compared to healthy individuals. |
| Who can participate | Inclusion Criteria: * Healthy subjects: competent adult (\>18 years) volunteers * Patients: adult (\<18 years) patients with Parkinson's disease, clinically confirmed by a movement disorder specialised neurologist with Hoehn and Yahr staging 1 to 3 * Willingness and ability to understand nature and content of the study * Ability to participate and comply with study requirements Exclusion Criteria: * Healthy subjects: previous or ongoing diseases of the central nervous system * Patients: previous or ongoing diseases of the central nervous system, other than Parkinson's disease * History of or current psychiatric treatment * History of or current brain surgery or epilepsy, unclusing deep brain stimulation * Neuromuscular disorders * Pre-existing pulmonary disease, such as chronic obstructive |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Radboud University Medical Center |
| Locations | Nijmegen, Gelderland, Netherlands |
| Start date | 2023-10-30 |
| NCT ID | NCT06074614 |
| Official listing | https://clinicaltrials.gov/study/NCT06074614 |