Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG)
The goal of this observational study is to to look for changes within the brain, and changes in body-to-brain signals in people with cancer and people who do not have cancer. The main questions it aims to answer are: 1. Are there differences in areas of the brain known to be related to appetite control, food reward and
| Condition(s) | Cancer, Cachexia, Cachexia-Anorexia Syndrome, Appetite Loss, Weight Loss |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The goal of this observational study is to to look for changes within the brain, and changes in body-to-brain signals in people with cancer and people who do not have cancer. The main questions it aims to answer are: 1. Are there differences in areas of the brain known to be related to appetite control, food reward and motivation, between participants with cancer related weight loss and healthy volunteers 2. Do responses to questionnaires and computer based tasks suggest participants with cancer related weight loss have reduced appetite and reduced motivation to eat compared to healthy volunteers, and if so, do questionnaires suggest that this is associated with any other symptoms? Researchers will compare the structure and blood flow in relevant areas of the brain using MRI images between |
| Who can participate | Inclusion Criteria: General inclusion criteria for all groups: * Written informed consent * Aged 18 years or over * Willing and able to comply with study procedures and visits Additional inclusion criteria for participants with cancer: * Histological or cytological diagnosis of cancer or confirmed non-intracranial malignancy on imaging. * Unintended documented weight loss of \>5% body weight in 6 months which is felt to be cancer related, OR patient reported weight loss and/or change in appetite Exclusion Criteria: General exclusion criteria for all groups: * Non-fluent English speaker * Active infection, as determined by the investigator based on clinical symptoms and / or fever and / or requirement for antibiotics * Women, who are pregnant, plan to become pregnant or are lactating. * MRI |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Cambridge |
| Locations | Cambridge, United Kingdom |
| Start date | 2024-02-15 |
| NCT ID | NCT06112964 |
| Official listing | https://clinicaltrials.gov/study/NCT06112964 |