New Screening and Diagnostic Cut-off Points of PA Patients
This study aims to establish the screening and diagnostic cut-off points for primary aldosteronism patients by a novel small molecule "sandwich method" aldosterone and renin chemiluminescent immunoassay.
| Condition(s) | Primary Aldosteronism |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This study aims to establish the screening and diagnostic cut-off points for primary aldosteronism patients by a novel small molecule "sandwich method" aldosterone and renin chemiluminescent immunoassay. |
| Who can participate | Inclusion Criteria: * 18-75y; * persistent hypertension (BP \>150/100 mm Hg), or drug-resistant hypertension; * newly diagnosed hypertension; * hypertension and spontaneous or diuretic-induced hypokalemia; * hypertension with adrenal incidentaloma; * hypertension and a family history of early-onset hypertension or cerebrovascular accident at a young age (\<40 years); * status as a hypertensive first-degree relative of patients with PA; * patients with hypertension and obstructive sleep apnea. Exclusion Criteria: * age \<18; BMI ≤ 18.0kg/m2 or ≥ 35.0 kg/m2; * a diagnosis of secondary hypertension other than PA; * chronic cardiac dysfunction (NYHA III-IV); * medium and several kidney dysfunction (Ccr\<30ml/min); * liver cirrhosis; * terminal malignant tumor; * recent use of steroids or oral |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Lead sponsor | China National Center for Cardiovascular Diseases |
| Locations | Beijing, China |
| Start date | 2024-01-04 |
| NCT ID | NCT06571084 |
| Official listing | https://clinicaltrials.gov/study/NCT06571084 |