Nociception Level Index After Brachial Plexus Block In Upper Extremity Surgery
The present prospective within-subject observational study will evaluate whether unilateral brachial plexus block (BPB) induces measurable lateralized autonomic modulation, assesses using bilateral Nociception Level (NoL) monitoring during standardized intraoperative stimuli under general anesthesia. Regional anesthesi
| Condition(s) | Brachial Plexus Blockade |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The present prospective within-subject observational study will evaluate whether unilateral brachial plexus block (BPB) induces measurable lateralized autonomic modulation, assesses using bilateral Nociception Level (NoL) monitoring during standardized intraoperative stimuli under general anesthesia. Regional anesthesia efficacy is traditionally assessed through sensory and motor examination. However, objective physiologic markers reflecting sympathetic modulation remain limited. Forty five adults undergoing upper extremity surgery with BPB and general anesthesia, bilateral NoL monitoring will be performed during local anesthetic injection, endotracheal intubation, and nasogastric tube placement. The primary aim to investigate whether the brachial plexus block induces unilateral modulation |
| Who can participate | Inclusion Criteria: * Age \>18 * Upper extremity surgery * Provision of signed and dated informed consent forms Exclusion Criteria: * Pregnant women * Known allergic reaction to bupivacaine or other anesthetic medicine: Midazolam, Fentanyl, Propofol, Rocuronium, Remifentanil, Sevoflurane) * Known coagulopathy resulting in bleeding tendency * Thrombocytopenia * Abnormal laboratory coagulation tests in the previous week = Anticoagulation therapy Participation in other study |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Carmel Medical Center |
| Locations | Haifa, Israel |
| Start date | 2023-03-28 |
| NCT ID | NCT07620002 |
| Official listing | https://clinicaltrials.gov/study/NCT07620002 |