Non-invasive Personalized Transcranial Cortical Neurostimulation for Pain Relief
Neuropathic pain is a public health problem with less than 50% of patients being relieved by drug treatments. Surgically implanted motor cortex stimulation represents an invasive therapeutic solution capable of relieving a significant proportion of drug-resistant patients (1 in 2); it cannot, however, be offered to all
| Condition(s) | Drug-resistant Neuropathic Pain |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Neuropathic pain is a public health problem with less than 50% of patients being relieved by drug treatments. Surgically implanted motor cortex stimulation represents an invasive therapeutic solution capable of relieving a significant proportion of drug-resistant patients (1 in 2); it cannot, however, be offered to all patients, and is not morbidity-free. Non-invasive motor cortex stimulation techniques have been refined over the last decade, in particular transcranial repetitive magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), which provide pain relief among almost half of drug-resistant patients with few or no side effects. To be efficient, cortical stimulation requires the activation of multiple distant networks involved in the cognitive and motivational r |
| Who can participate | Inclusion Criteria: * Aged 18 to 80 years * Neuropathic pain of more than one year's duration1 * Failed treatment with tricyclic or tetracyclic antidepressants, antiepileptics and a combination of morphine and a serotonin (5HT) norepinephrine (NA2) reuptake inhibitor, in the absence of contraindication. * Average pain intensity of at least 4/10 in the month preceding the inclusion visit. * Recipient or beneficiary of a social security scheme- Exclusion Criteria: * Chronic non-neuropathic pain or pain associated with progressive pathology, active epilepsy, unhealed scalp wound, impaired comprehension or communication that prevents subjective daily and weekly assessments. * Active epilepsy, treated or not * Unhealed scalp wound adjacent to EEG recording electrodes or transcranial stimulation |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Lead sponsor | Hospices Civils de Lyon |
| Locations | Bron, France |
| Start date | 2025-04-10 |
| NCT ID | NCT06209645 |
| Official listing | https://clinicaltrials.gov/study/NCT06209645 |