Observational Study on Energy Expenditure and Protein Metabolism Changes in Patients With
Evaluation of early energy metabolism and muscle mass changes in patients with severe brain injury, the impact of nutritional therapy on metabolism and muscle mass, and their relationship with patient prognosis, to provide clinical research references for the implementation of individualized nutritional therapy in pati
| Condition(s) | Energy Metabolism and Muscle Mass Changes in Patients With Severe Brain Injury |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Evaluation of early energy metabolism and muscle mass changes in patients with severe brain injury, the impact of nutritional therapy on metabolism and muscle mass, and their relationship with patient prognosis, to provide clinical research references for the implementation of individualized nutritional therapy in patients with severe brain injury. |
| Who can participate | Inclusion Criteria: * Patients with severe neurological critical illness admitted to the ICU, including moderate to severe acute cerebrovascular disease, severe acute craniocerebral injury and spinal cord injury, central nervous system bacterial infections, status epilepticus, neurosurgical patients requiring life support during the perioperative period, and other progressive severe neurological conditions. * Age ≥ 18 years old. * Receiving invasive mechanical ventilation. * Willing to sign an informed consent form. Exclusion Criteria: * Women of childbearing age with a positive pregnancy test, pregnant, or lactating women. * Chronic diseases with severe organ dysfunction or serious complications: 1. Heart: New York Heart Association (NYHA) Functional Classification IV. 2. Lung: Chronic re |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Lead sponsor | Southeast University, China |
| Locations | Nanjing, Jiangsu, China |
| Start date | 2024-04-15 |
| NCT ID | NCT06577402 |
| Official listing | https://clinicaltrials.gov/study/NCT06577402 |