Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS
Non-tracheal intubated combined anesthesia with preserved spontaneous breathing significantly enhances the quality and speed of recovery post-VATS for patients undergoing lung nodule surgery. The "opioid-sparing strategy," which substitutes ketamine for opioids during surgery, not only provides effective analgesia but
| Condition(s) | Video-assisted Thoracoscopic Lung Surgery；Anesthesia |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Non-tracheal intubated combined anesthesia with preserved spontaneous breathing significantly enhances the quality and speed of recovery post-VATS for patients undergoing lung nodule surgery. The "opioid-sparing strategy," which substitutes ketamine for opioids during surgery, not only provides effective analgesia but also protects perioperative lung function and reasonably prevents the occurrence of opioid-related adverse reactions; it also reduces medical costs and shortens the average hospital stay. However, the degree of benefit to patients lacks high-level clinical evidence. This study aims to comprehensively assess the effect of opioid-free combined anesthesia with preserved spontaneous breathing for VATS lung nodule surgery on postoperative rapid recovery from multiple aspects inclu |
| Who can participate | Inclusion Criteria: 1. ASA grades 1-2 2. Age \> 18 years and \< 70 years 3. Male or female patients 4. VATS pulmonary nodule operation is planned under general anesthesia 5. Voluntarily participate in the study and sign the informed consent Exclusion Criteria: 1. Subject's operation is aborted 2. Serious adverse events, complications or special physiological changes during the perioperative period should not be continued 3. Expansion of surgical scope: resection of complex lung segment or complex lung lobectomy, thoracoscopic assisted small-incision surgery with enlarged incision, requiring pulmonary blood Tracheoplasty or bronchoplasty, partial pericardiectomy or conversion to thoracotomy 4. Those who need a second operation within a month 5. The patient or his/her guardian requests to wi |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Lead sponsor | Tongji Hospital |
| Locations | Wuhan, Hubei, China |
| Start date | 2024-10-01 |
| NCT ID | NCT06367218 |
| Official listing | https://clinicaltrials.gov/study/NCT06367218 |