Optimising HFO&VTV in Newborn Infants
Mechanical ventilation (MV) is life saving for infants requiring respiratory support in the newborn period but its use has been associated with complications. High frequency oscillation (HFO) is a type of MV that delivers small volumes of gas across the lungs at fast frequencies. HFO is a lung protective strategy but i
| Condition(s) | High Frequency Oscillation, Volume Targeted Ventilation |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Mechanical ventilation (MV) is life saving for infants requiring respiratory support in the newborn period but its use has been associated with complications. High frequency oscillation (HFO) is a type of MV that delivers small volumes of gas across the lungs at fast frequencies. HFO is a lung protective strategy but it has also been linked to brain injury due to low carbon dioxide tensions. High-frequency oscillation with volume-targeted ventilation (HFO\&VTV) is a new mode of HFO in which the clinician sets a target volume of gas to be delivered to the lungs at fast rates to decrease the lung injury related to the ventilator. Further, HFO\&VTV achieves better control of carbon dioxide levels and may therefore protect against brain injury. Currently, there are no written guidelines about |
| Who can participate | Inclusion Criteria: -Newborn infants of any gestation receiving high frequency oscillatory ventilation Exclusion Criteria: * Infants with known intracerebral pathology (stroke, hydrocephalus, intracerebral hemorrhage, severe hypoxic ischemic encephalopathy). * Infants with congenital cardiac abnormalities. |
| Ages | 22 Weeks to 1 Year |
| Sex | All |
| Lead sponsor | King's College Hospital NHS Trust |
| Locations | London, United Kingdom |
| Start date | 2025-02-26 |
| NCT ID | NCT06719284 |
| Official listing | https://clinicaltrials.gov/study/NCT06719284 |