Optimising Pacing for Contractility 2
The investigators have demonstrated that they can reliably identify an optimum heart rate range for contractility of the left ventricle in patients with chronic heart failure (CHF). They have also demonstrated in an acute cross-over and a small parallel group feasibility study that keeping the heart rate in this range
| Condition(s) | Heart Failure, Systolic, Pacemaker |
|---|---|
| Status | Recruiting |
| Phase | Phase 2, Phase 3 |
| Study type | Interventional |
| Summary | The investigators have demonstrated that they can reliably identify an optimum heart rate range for contractility of the left ventricle in patients with chronic heart failure (CHF). They have also demonstrated in an acute cross-over and a small parallel group feasibility study that keeping the heart rate in this range (versus standard rate-response programming) in patients with CHF is associated with increased exercise time on a treadmill (around 60s or 10%). They now want to explore in a randomised, placebo-controlled 3-arm parallel group trial whether optimal programming versus standard rate-response programming versus no rate-response programming for 6 months leads to appreciable improvements in exercise time and quality of life, while having no adverse effects on left ventricular funct |
| Who can participate | Inclusion Criteria: * Clinical, echocardiographic and neurohormonal evidence of heart failure * Cardiac pacemaker, * Able to perform a peak exercise test, * Willing and able to give informed consent. Exclusion Criteria: * Angina pectoris symptoms limiting exercise tolerance, * Unstable heart failure symptoms (medical therapy changes in last three months), Poor image quality, * Calcium channel blockers (CCBs). |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | University of Leeds |
| Locations | Leeds, United Kingdom |
| Start date | 2020-06-01 |
| NCT ID | NCT04201015 |
| Official listing | https://clinicaltrials.gov/study/NCT04201015 |