Optimization of ITBS for Depression
Repetitive TMS (rTMS) is a well-established method for modulating brain activity. Through successive stimulations in the form of magnetic fields, it is possible to modify the sensitivity of neurons in the brain, also known as cortical excitability. Cortical excitability is important for the induction of brain plasticit
| Condition(s) | Neuromodulation |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Repetitive TMS (rTMS) is a well-established method for modulating brain activity. Through successive stimulations in the form of magnetic fields, it is possible to modify the sensitivity of neurons in the brain, also known as cortical excitability. Cortical excitability is important for the induction of brain plasticity, the ability of the brain to reorganize itself and form new connections in response to stimuli. A particular class of rTMS, intermittent theta burst TMS (iTBS), is commonly used to modulate cortical excitability and induce plasticity for therapeutic purposes, notably for treatment-resistant depression. Different iTBS stimulation parameters can be used to induce plasticity. This study will focus on two parameters, namely, the form and duration of the electromagnetic stimulat |
| Who can participate | Inclusion Criteria: * Be between 18 and 35 years old * Be of right manual dominance * In good health Exclusion Criteria: * Have an implant or pacemaker, * Having tinnitus, * Have a history of fainting, * Have already had an epileptic seizure or have a family history of epilepsy, * Have a known neurological disease, * Be under psychotropic medication, * Have suffered from substance abuse or dependence in the last 6 months, * Have a neurostimulator, * Have a splinter or metallic implant in the head or the rest of the body, * Have a cochlear implant, * Have an automated injection system implanted (insulin pump), * Have a transdermal patch, * Have tattoos in the area to be studied, * Be pregnant or breastfeeding, |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Université de Sherbrooke |
| Locations | Sherbrooke, Quebec, Canada |
| Start date | 2024-08-01 |
| NCT ID | NCT06464445 |
| Official listing | https://clinicaltrials.gov/study/NCT06464445 |