Optimizing Pulsatility During Cardiopulmonary Bypass
Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs. Blood flow during cardiopulmonary bypass may be pulsatile or non-pulsatile, which may impact normal organ function after surgery. The study will collect data on the type of cardiopul
| Condition(s) | Endothelial Dysfunction, Acute Kidney Injury |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs. Blood flow during cardiopulmonary bypass may be pulsatile or non-pulsatile, which may impact normal organ function after surgery. The study will collect data on the type of cardiopulmonary bypass used during surgery and organ function to determine if there is an association between the type of bypass and organ function. |
| Who can participate | Inclusion Criteria: * Age 50 to 70 * Able to provide informed consent * Scheduled for elective cardiac surgery with cardiopulmonary bypass Exclusion Criteria: * Patients undergoing emergency procedures * Diagnosed with sepsis * Experiencing delirium * Experiencing hemodynamic instability (heart rate \> 100 and systolic blood pressure \< 90) * Patients with a mechanical circulatory support device * Requiring vasoactive medications before surgery * Patients with a reduced left ventricular ejection fraction (less than 50%) * Patients with a contraindication to transesophageal echocardiography |
| Ages | 50 Years to 70 Years |
| Sex | All |
| Lead sponsor | University of Colorado, Denver |
| Locations | Aurora, Colorado, United States |
| Start date | 2022-07-05 |
| NCT ID | NCT05344573 |
| Official listing | https://clinicaltrials.gov/study/NCT05344573 |