Pancreatic Cancer Evolution Upon Treatment
This project aims at evaluating the different subtypes of pancreatic cancer on EUS-tissue acquisition of pancreatic cancer patients, and their possible modifications throughout time. The study takes advantage of a systematic evaluation of pancreatic cancers through diagnostic EUS-guided fine needle biopsy (FNB) samplin
| Condition(s) | Pancreatic Cancer |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This project aims at evaluating the different subtypes of pancreatic cancer on EUS-tissue acquisition of pancreatic cancer patients, and their possible modifications throughout time. The study takes advantage of a systematic evaluation of pancreatic cancers through diagnostic EUS-guided fine needle biopsy (FNB) sampling of the mass performed during a restaging EUS. FNB samples represent a valuable source of cancer cells, both for the histological diagnosis and as the source of tumor macromolecules, including DNA and RNA. Study design This is a prospective study enrolling patients with non-metastatic pancreatic cancer who already underwent diagnostic EUS with tissue acquisition and rapid on-site evaluation (ROSE) by cytologist positive for pancreatic cancer, with a first sample acquired for |
| Who can participate | Inclusion Criteria: * Age ≥ 18 years * Willing to sign informed consent * Patient with CT scan or MRI or EUS defining the lesion as locally advanced * Patient who already underwent EUS-TA for solid lesion of the pancreas positive for pancreatic ductal adenocarcinoma (PDAC) * Patient undergoing neoadjuvant chemotherapy * Patient primarily followed at San Raffaele Hospital Exclusion Criteria: * Patients not willing to sign informed consent * Pregnancy and breastfeeding * Cytology positive for malignancies other than PDAC * Patient undergoing progression at re-staging CT scan |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | IRCCS San Raffaele |
| Locations | Milan, Italy |
| Start date | 2021-07-14 |
| NCT ID | NCT05195281 |
| Official listing | https://clinicaltrials.gov/study/NCT05195281 |