Pathophysiological Mechanisms and Implication of Treatment in Postural Puncture Headache
To improve treatment for post dural puncture headache, its pathophysiology needs to be explored. Dural puncture alters CNS dynamics; using advanced MRI, we aim to investigate PDPHs pathophysiology explained by brain movement, cerebral blood flow, CSF dynamics and the effect of epidural blood patch.
| Condition(s) | Post-Dural Puncture Headache |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | To improve treatment for post dural puncture headache, its pathophysiology needs to be explored. Dural puncture alters CNS dynamics; using advanced MRI, we aim to investigate PDPHs pathophysiology explained by brain movement, cerebral blood flow, CSF dynamics and the effect of epidural blood patch. |
| Who can participate | Inclusion Criteria: Postural puncture headache Age 20-40 Exclusion Criteria: * Other central neurological disorders except the actual * Acute medical condition * Pregnancy * Pacemaker, or other medical implants that are not MRI-compatible * Invasive procedures on the central nervous system or surgery on the spine or brain in the last 12 months. |
| Ages | 20 Years to 40 Years |
| Sex | All |
| Lead sponsor | Umeå University |
| Locations | Umeå, Västerbotten County, Sweden |
| Start date | 2024-01-30 |
| NCT ID | NCT06253754 |
| Official listing | https://clinicaltrials.gov/study/NCT06253754 |