PEEP FOR LUNG RECRUITMENT IN PRETERM INFANTS-EIT STUDY
Babies born early (under 32 weeks) are at risk of developing lung problems after birth. A major reason for this is that the lungs are not fully developed. Lungs of preterm babies will often collapse in between breathing due to lung immaturity. Applying gentle pressure, using nasal device through their nostril or throug
| Condition(s) | PreTerm Neonate, Positive End Expiratory Pressure (PEEP), Lung Recruitment, Electrical Impedance Tomography (EIT) |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Babies born early (under 32 weeks) are at risk of developing lung problems after birth. A major reason for this is that the lungs are not fully developed. Lungs of preterm babies will often collapse in between breathing due to lung immaturity. Applying gentle pressure, using nasal device through their nostril or through the breathing tube helps to prevent this lung collapse. This would help in air-oxygen going to lungs and also makes the babies breathing more comfortable. This gentle pressure is medically called as PEEP/CPAP and could be delivered by breathing machine (ventilator) and CPAP machine, collectively called as "continuous distending pressure (CDP)". Those babies breathing on their own and receiving inadequate CDP would need more breathing support by placing them on breathing mac |
| Who can participate | Inclusion criteria 1. Gestational age \<32 weeks based on mother's last menstrual period or first trimester ultrasound dating. 2. Receiving either CPAP or mechanical ventilation respiratory support. 3. Informed written consent from one of the parents. 4. Within the first two weeks of life. Investigators pragmatically chose this period, as there could be considerable lung injury after the first two weeks of life, making it difficult to test our hypothesis. Also, this time period would allow parents to settle down with their stressful preterm delivery and investigators could approach anytime within the first two weeks of life. Exclusion criteria 1. Major congenital malformations including congenital lung disease and congenital heart disease as ascertained by the medical team. 2. Infants diag |
| Ages | 22 Weeks to 32 Weeks |
| Sex | All |
| Lead sponsor | South Tees Hospitals NHS Foundation Trust |
| Locations | Middlesbrough, United Kingdom |
| Start date | 2025-06-15 |
| NCT ID | NCT06705257 |
| Official listing | https://clinicaltrials.gov/study/NCT06705257 |