Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability
This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung recruitability.
| Condition(s) | Respiratory Distress Syndrome, Positive-Pressure Respiration, Mechanical Ventilation |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung recruitability. |
| Who can participate | Inclusion Criteria: 1. age ≥18 years 2. Moderate-to-severe ARDS as per the 2023 ESICM definition 3. Undergoing invasive mechanical ventilation 4. Planned prone position based on the attending physicians' decisions 5. Signed informed consent Exclusion Criteria: 1. age ≥85 years 2. Pregnancy 3. Severe hemodynamic instability (\> 30% increase in vasopressors in the last 6 hours or norepinephrine \> 0.5 µg/kg/min) 4. Clinically suspected elevated intracranial pressure (\>18 mm Hg) 5. Bronchopleural fistula 6. Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement) 7. Severe hypernatremia (\>170mmol/L) 8. Re-admission of patients already enrolled in this study, or patients who are participating in other studies |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Lead sponsor | Zhongda Hospital |
| Locations | Nanjing, Jiangsu, China |
| Start date | 2024-06-08 |
| NCT ID | NCT06430554 |
| Official listing | https://clinicaltrials.gov/study/NCT06430554 |