PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620
The investigators will compare \[18F\]-PI-2620 tau PET scans from patients with frontotemporal lobar degeneration (FTLD), patients with non-amnestic presentations of Alzheimer's disease (naAD), and demographically matched cognitively normal subjects.
| Condition(s) | Frontotemporal Lobar Degeneration, Alzheimer Disease, Cognitively Normal |
|---|---|
| Status | Recruiting |
| Phase | Phase 3 |
| Study type | Interventional |
| Summary | The investigators will compare \[18F\]-PI-2620 tau PET scans from patients with frontotemporal lobar degeneration (FTLD), patients with non-amnestic presentations of Alzheimer's disease (naAD), and demographically matched cognitively normal subjects. |
| Who can participate | Inclusion Criteria: participants must fulfill all of the criteria for one of the following groups. 1\. Group 1: cognitively and neurologically normal subjects (CN, n=25) 1. Male or female ≥ 18 years of age currently enrolled in UNICORN (IRB #842873) 2. Cognitively and neurologically normal according to one of the following criteria: i. Mini-Mental Status Exam (MMSE; Folstein et al., 1975) score \> 27, OR ii. Montreal Cognitive Assessment (MoCA; Carson et al., 2017; Nasreddine et al., 2005) score \> 25, OR iii. Global Clinical Dementia Rating of 0, OR iv. Evaluation by a trained clinician 3. Not clinically depressed, according to one of the following criteria: i. Geriatric Depression scale ≤ 6 (assessed ≤ 6 months prior to study enrollment), OR ii. Evaluation by a trained clinician 4. No hi |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Pennsylvania |
| Locations | Philadelphia, Pennsylvania, United States |
| Start date | 2022-09-19 |
| NCT ID | NCT05456503 |
| Official listing | https://clinicaltrials.gov/study/NCT05456503 |