Pharmacokinetic Study of Topical Phenylephrine
Pharmacokinetic Study of Topical Phenylephrine
| Condition(s) | Chemotherapy Induced Alopecia, Chemotherapy Side Effects |
|---|---|
| Status | Recruiting |
| Phase | EARLY_Phase 1 |
| Study type | Interventional |
| Summary | Pharmacokinetic Study of Topical Phenylephrine |
| Who can participate | Inclusion Criteria: * Healthy females, age 18-55 * BMI: 18-30 kg/m² * Fitzpatrick Skin Types I-IV (to standardize absorption risk) * Scalp free from irritation, dermatologic disease, or damage * Able to refrain from using other topical scalp products Exclusion Criteria: * History of cardiovascular disease, hypertension, or arrhythmia * Scalp infections, wounds, or significant hair loss * Recent use of medications that interfere with CYP enzymes or adrenergic systems * Known sensitivity to phenylephrine or ethanol * Positive drug screen or abnormal ECG at screening |
| Ages | 18 Years to 55 Years |
| Sex | Female |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Applied Biology, Inc. |
| Locations | Rome, Italy |
| Start date | 2025-06-30 |
| NCT ID | NCT07033845 |
| Official listing | https://clinicaltrials.gov/study/NCT07033845 |