Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in
Asthma is a heterogeneous disorder in which multiple potential inflammatory pathways contribute to airway obstruction. The biological basis for airway inflammation is the subject of intensive investigation. This work is designed to identify airway factors that are responsible for recruiting cells and associate their ai
| Condition(s) | Asthma |
|---|---|
| Status | Recruiting |
| Phase | Phase 1 |
| Study type | Interventional |
| Summary | Asthma is a heterogeneous disorder in which multiple potential inflammatory pathways contribute to airway obstruction. The biological basis for airway inflammation is the subject of intensive investigation. This work is designed to identify airway factors that are responsible for recruiting cells and associate their airway presence with atopy and asthma. |
| Who can participate | A. Subjects with Allergic Asthma (AA subjects) Inclusion Criteria: 1. All subjects will have a baseline FEV1 determined at the characterization visit that is no less than 75 % of the predicted value. 2. All subjects will have a clinical history of allergic symptoms to cat or dust mite allergen and demonstrated skin reactivity (a positive allergen prick test). 3. Life-long absence of cigarette smoking (defined as a lifetime total of less than 5 pack-years); none in 5 years). 4. Willing and able to give informed consent. 5. Expressed the desire to participate in an interview with the principal investigator. 6. Age between 18 and 50 years. Exclusion Criteria: 1. Women of childbearing potential who are documented to be pregnant (based on Urine beta-HCG testing), are sexually active and not usi |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Benjamin Medoff |
| Locations | Boston, Massachusetts, United States |
| Start date | 2008-01 |
| NCT ID | NCT00595491 |
| Official listing | https://clinicaltrials.gov/study/NCT00595491 |