PITCHER (Peritoneal Carcinomatosis Heterogeneity)
How epigenetic deregulation affects gene expression patterns in subclones of the same tumor is poorly known. Peritoneal Carcinomatosis (PC) is a condition in which multiple metastases of the same abdominal tumor develop in the peritoneal cavity and intra-peritoneal organs, thus defining different ecosystems of the same
| Condition(s) | Secondary Peritoneal Cancers, Colorectal Cancer, Ovarian Cancer |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | How epigenetic deregulation affects gene expression patterns in subclones of the same tumor is poorly known. Peritoneal Carcinomatosis (PC) is a condition in which multiple metastases of the same abdominal tumor develop in the peritoneal cavity and intra-peritoneal organs, thus defining different ecosystems of the same cancer. PITCHER addresses the variations in epigenetically regulated gene expression between different subclones of PC in relation with cell mechanoresponses, providing insights on how cancer epigenetic landscapes evolve under environmental pressures and on strategies used by cancer cells to adapt to the transition from one ecosystem to the other. PITCHER is a network of 10 teams from Lyon, Grenoble and Marseille, based on data and specimen collection of patients who have un |
| Who can participate | Inclusion Criteria: * Patients who accept to participate to the study * Men / women aged over 18 years * Patients with cancer management and care for peritoneal carcinomatosis of digestive or ovarian origin * Patients had histologic/radiologic confirmation of peritoneal disease * Serology negative HIV, HEPATITIS Exclusion Criteria: • none |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Hospices Civils de Lyon |
| Locations | Lyon, France |
| Start date | 2020-09-01 |
| NCT ID | NCT04714957 |
| Official listing | https://clinicaltrials.gov/study/NCT04714957 |