Polyphenols and Cognitive Decline
Globally, populations are aging thereby increasing healthcare burden, overall cognitive impairment, and dementia including Alzheimers diseases (AD). The lack of effective treatments makes it essential to develop new strategies for healthy cognitive aging, including interventions to slow or prevent cognitive decline. A
| Condition(s) | Cognitive Decline, Cognitive Dysfunction |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Globally, populations are aging thereby increasing healthcare burden, overall cognitive impairment, and dementia including Alzheimers diseases (AD). The lack of effective treatments makes it essential to develop new strategies for healthy cognitive aging, including interventions to slow or prevent cognitive decline. A traditional Mediterranean diet, rich in polyphenols (PPs), may prevent or delay the onset of cognitive dysfunction in older adults, preserving healthy brain structure and function, and lowering the risk of AD. These effects, mediated in part by gut microbiome-derived PP metabolites, highlight the role alterations in the brain-gut microbiome system play in neurodegeneration. Moreover, high levels of circulating phenyl-y-valerolactones, neuroprotective compounds, exclusively pr |
| Who can participate | Inclusion Criteria: * 50+ Years of age * Male or Female * At enhanced risk of Alzheimer's Disease (defined as family history of AD, 1st degree family member) * Habitually consume suboptimal diets such as typical Western Diet (i.e., high in animal products, refined carbohydrates and processed food) * Able to communicate well in English Exclusion Criteria: * Vegan or Vegetarian * Presence of cognitive impairment at the time of recruitment into the study as measured by the Mini Mental Status Exam (MMSE, score 25-30) and Clinical Dementia Rating (CDR, score=0). * Pre-existing psychosis or psychiatric conditions * Currently receiving treatment for dementia * History of alcohol and/or substance abuse/dependence as determined by a positive endorsement on the MINI+/ If the MINI+ is positive for al |
| Ages | 50 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of California, Los Angeles |
| Locations | Los Angeles, California, United States |
| Start date | 2025-01-09 |
| NCT ID | NCT06507254 |
| Official listing | https://clinicaltrials.gov/study/NCT06507254 |