Postnatal Steroids Effects on Cardiac Function in Extremely Preterm
Hypothesis/Study question In infants born at less than 29 weeks of estimated gestational age, what are the effects of dexamethasone use on cardiac structure/performance and lung water content? Study objectives To measure effects before and after dexamethasone administration on cardiac structure/performance will be eval
| Condition(s) | Left Ventricular Hypertrophy |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Hypothesis/Study question In infants born at less than 29 weeks of estimated gestational age, what are the effects of dexamethasone use on cardiac structure/performance and lung water content? Study objectives To measure effects before and after dexamethasone administration on cardiac structure/performance will be evaluated by using the M-mode technique (Devereux method (25-27) and lung water content will be specifically determined by the degree of water retention in premature lungs assessed by lung ultrasound at the pre specified time points. Methodology / Study design Single center, prospective observational cohort study planning to enroll eligible patients over a period of 12 months |
| Who can participate | Inclusion Criteria: * \< 29 weeks of gestational age at birth admitted at the McGill University Children Hospital's neonatal intensive care unit * To be initiated on dexamethasone therapy for treatment of significant lung disease as per medical team decision. Exclusion Criteria: * Congenital heart disease (except: Atrial septum defect (ASD), Ventricular septum defect (VSD) * Major congenital anomalies/genetic disorder (Trisomy 13, 18, 21) * Congenital severe lung or airway malformation (Trachea-esophageal fistula, congenital pulmonary airway malformation, congenital diaphragmatic hernia) * Twin-twin transfusion syndrome |
| Ages | 1 Minute |
| Sex | All |
| Lead sponsor | McGill University Health Centre/Research Institute of the McGill University Health Centre |
| Locations | Montreal, Quebec, Canada |
| Start date | 2021-06-15 |
| NCT ID | NCT04644094 |
| Official listing | https://clinicaltrials.gov/study/NCT04644094 |