Postoperative Radiotherapy for Intermediate- and High-risk Patients With HNSCC Greater Tha
The goal of this clinical trial is to determine whether accelerated radiotherapy (involving 6 treatments per week) is better than standard radiotherapy (involving 5 treatments per week) at treating cancer of the head and neck when initiated more than 6 weeks after surgery.
| Condition(s) | Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma HNSCC |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The goal of this clinical trial is to determine whether accelerated radiotherapy (involving 6 treatments per week) is better than standard radiotherapy (involving 5 treatments per week) at treating cancer of the head and neck when initiated more than 6 weeks after surgery. |
| Who can participate | Inclusion Criteria: * Pathologically confirmed head and neck squamous cell carcinoma of the oral cavity, oropharynx, larynx, hypopharynx, sinus, or lymph nodes of the neck of unknown primary. * Planned for curative intent postoperative radiotherapy based on pathologic risk factors. * Patients with non-HPV-mediated oropharyngeal squamous cell carcinoma or non-oropharyngeal squamous cell carcinoma must have at least one of the following: pathologic tumor classification pT3-4, multiple lymph nodes involved with cancer, perineural invasion, lymphovascular invasion, close margins (within 2 mm for oropharyngeal cancer status post transoral resection; within 5 mm for all others) or cleared margins (initially positive, subsequently cleared in an additional specimen), extranodal extension (any exte |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Wake Forest University Health Sciences |
| Locations | Charlotte, North Carolina, United States; Winston-Salem, North Carolina, United States; Milwaukee, Wisconsin, United States |
| Start date | 2025-01-21 |
| NCT ID | NCT06607406 |
| Official listing | https://clinicaltrials.gov/study/NCT06607406 |