PREnatal Choline and Infant Outcomes Study
Less than 10% of pregnant women consume adequate levels of choline, an essential nutrient for maternal lipid metabolism, placental efficiency, and fetal development. Most prenatal vitamins do not contain choline; a research survey shows that only 6% of OB/GYNs were likely to recommend choline-rich foods to pregnant wom
| Condition(s) | Nutrition During Pregnancy |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Less than 10% of pregnant women consume adequate levels of choline, an essential nutrient for maternal lipid metabolism, placental efficiency, and fetal development. Most prenatal vitamins do not contain choline; a research survey shows that only 6% of OB/GYNs were likely to recommend choline-rich foods to pregnant women. Nutrition education grounded in the Health Belief Model (HBM) has high efficacy among pregnant women; therefore, it is likely that HBM-driven choline education intervention will increase maternal choline levels. No studies have evaluated the influence of prenatal choline education intervention on maternal, placental, and neonatal outcomes. Our preliminary data suggest that increased choline intake corresponds with lower maternal body fat percentage (BF%), infant 1-month B |
| Who can participate | Inclusion Criteria: * Healthy pregnant individual * Singleton pregnancy * 18-40 years of age * Pre-pregnancy BMI ≥ 18.5 Exclusion Criteria: * Any non-pregnancy-related illness or chronic condition that may impact fetal development (i.e., HIV, cancer, heart disease, pre-existing diabetes) or known fetal anomaly * Food allergy to choline-rich foods (i.e., eggs) * Multi fetal pregnancy * \>40 years of age |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Accepts healthy volunteers | Yes |
| Lead sponsor | East Carolina University |
| Locations | Greenville, North Carolina, United States |
| Start date | 2025-05-15 |
| NCT ID | NCT07525193 |
| Official listing | https://clinicaltrials.gov/study/NCT07525193 |