Pressure Recording Analytical Method Parameters and Their Relationship With Hypotension in
Perioperative anesthesiologists can benefit from easily obtainable hemodynamic variables detecting or quantifying the lack of an adequate compensatory capacity of the cardiovascular system in order to optimize patient management and improve patient outcomes. Parameters of the Pressure Recording Analytical Method (PRAM;
| Condition(s) | Cardiovascular Diseases, Surgery, Hypotension, Hypotension on Induction, Hypotension During Surgery |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Perioperative anesthesiologists can benefit from easily obtainable hemodynamic variables detecting or quantifying the lack of an adequate compensatory capacity of the cardiovascular system in order to optimize patient management and improve patient outcomes. Parameters of the Pressure Recording Analytical Method (PRAM; Vygon, Padua, Italy) of the MostCare system, specifically cardiac cycle efficiency has been proposed as such variables. Yet, their value in anesthesia and especially in hypertensive patients is not studied. The goal of the PRAM-in-HYPO study is to prospectively evaluate the relationship between cardiac reserve and efficiency and cardiovascular risk factors in patients wo will undergo major surgical procedures using the state-of-the-art hemodynamic monitors. Also the investig |
| Who can participate | Inclusion Criteria: * Age at least 18 years * Undergoing major surgery under general anesthesia * Expected surgery time \>2 h * Expected length of postoperative stay \>2 d * Invasive blood pressure (radial or femoral) and Mostcare monitoring * Indication for a passive leg raising test: risk of hypovolemia (preoperative fasting, bowel preparation, loss of appetite, limited access to water) or expected major surgery, expected blood loss, cardiovascular comorbidity (hypertension, diabetes mellitus, coronary artery disease, peripheral artery disease, hyperlipidemia, morbidity, active smoking). * Recruitment after booking for surgery with sufficient time to read, understand and question study patient information prior to attending for surgery. * Ability and willingness to provide informed conse |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Recep Tayyip Erdogan University |
| Locations | Ankara, Turkey (Türkiye); Erzurum, Turkey (Türkiye); Istanbul, Turkey (Türkiye); Istanbul, Turkey (Türkiye); Rize, Turkey (Türkiye) |
| Start date | 2024-02-19 |
| NCT ID | NCT05960604 |
| Official listing | https://clinicaltrials.gov/study/NCT05960604 |