Prognostic Value of High-resolution Electrical Source Imaging on the Success of Pediatric
This study investigates the usefulness of high resolution electrical source imaging (HR-ESI) in the setting of presurgical evaluation of drug-resistant focal epilepsy in children. This method is based on an estimation of the intra-cerebral source that produces a signal recorded by scalp electrodes by solving the invers
| Condition(s) | Epilepsy in Children |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This study investigates the usefulness of high resolution electrical source imaging (HR-ESI) in the setting of presurgical evaluation of drug-resistant focal epilepsy in children. This method is based on an estimation of the intra-cerebral source that produces a signal recorded by scalp electrodes by solving the inverse problem, taking into account attenuation factors resulting from particular conductivity properties of the cerebral, peri-cerebral and cranial tissues. Electrical sources are then fused on structural magnetic resonance imaging (MRI). Scalp EEG recorded using 64 to 256 electrodes refers to as high resolution EEG (HR-EEG), leading to HR-ESI. Studies based on small population of children or on mixt population of children and adults showed that HR-ESI has accuracy values, i.e. p |
| Who can participate | Inclusion Criteria: 1. Ageā„2 and \<17 years; 2. Drug-resistant focal epilepsy (failure of at least 2 well-conducted drug trials); 3. Phase 1 pre-op evaluation with scalp video-EEG recording, MRI and PET-FDG suggesting that the patient could be a good candidate for epilepsy surgery; 4. Recent scalp EEG record (within 12 months) showing the presence of interictal spikes; 5. High-quality and recent (within 6 months) structural MRI with 3D-T1 sequences covering the whole brain and the scalp available. Exclusion Criteria: 1. Behavioral deficits making recording of scalp EEG impossible without sedation; 2. Informed consent form not signed by the parents; 3. Patient not affiliated to a social security system |
| Ages | 2 Years to 17 Years |
| Sex | All |
| Lead sponsor | University Hospital, Angers |
| Locations | Angers, France; Lille, France; Lyon, France; Marseille, France; Nancy, France; Paris, France (+3 more sites) |
| Start date | 2024-05-15 |
| NCT ID | NCT06271785 |
| Official listing | https://clinicaltrials.gov/study/NCT06271785 |