Progression of Metabolic Syndrome Components During Pregnancy
The goal of this cohort study is to investigate the underlying risk factors to develop metabolic syndrome (MetS) during pregnancy, and the associations of MetS and its indicators with birth outcomes in southwest Ethiopia. The study population consists of low-risk pregnant ladies in their first antenatal care visit (ANC
| Condition(s) | Metabolic Syndrome, Pregnant Women, Birth Outcomes, Dietary Habits, Knowledge, Attitudes, Practice |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The goal of this cohort study is to investigate the underlying risk factors to develop metabolic syndrome (MetS) during pregnancy, and the associations of MetS and its indicators with birth outcomes in southwest Ethiopia. The study population consists of low-risk pregnant ladies in their first antenatal care visit (ANC), from Jimma Medical center. The main question\[s\] it aims to answer are: i) How do MetS components progress during pregnancy, and what are the underlying risk factors? ii) What is the association between MetS components during early- and late pregnancy and adverse pregnancy outcomes? iii) What is the knowledge, attitude and practices of women toward dietary habits, food taboos, and cultural beliefs during pregnancy? The study population consists of low-risk pregnant ladies |
| Who can participate | Inclusion Criteria: * Apparently healthy women with (or without) at least one of the 5 individual components of MetS will be enrolled in the study from each selected health institution if they meet all the inclusion criteria. Inclusion criteria for the exposed group include additionally: 1. Abdominal obesity defined as waist circumference ≥ 2 standard deviations (SD) for gestational age in the first half of pregnancy or presentational BMI \>30 kg/m2, OR 2. Raised triglycerides (\>1.70 mmol/l \[\>150 mg/dl\]), OR 3. Reduced high-density lipoprotein cholesterol (\<1.29 mmol/l \[\<50 mg/dl\]), OR 4. Raised blood pressure (BP) (i.e., systolic BP \>130 mm Hg or diastolic BP \>85 mm Hg), OR 5. Raised plasma glucose (\>5.6 mmol/l). Exclusion Criteria: * Pregnant women with chronic hypertension th |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University Ghent |
| Locations | Jimma, Ethiopia |
| Start date | 2023-06-27 |
| NCT ID | NCT05935904 |
| Official listing | https://clinicaltrials.gov/study/NCT05935904 |