Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Im
The most common imaging procedure requiring sedation/anesthesia for the pediatric population is magnetic resonance imaging (MRI). However, the optimal anesthetic/sedation plan has not been determined for these procedures. Historically, common medications have included the use of pentobarbital and propofol, but in 2015,
| Condition(s) | MRI Sedation, Pediatric Sedation, Propofol Dosage, Emergence Delirium, Anesthesia, Recovery Time, Dexmedetomidine |
|---|---|
| Status | Recruiting |
| Phase | Phase 4 |
| Study type | Interventional |
| Summary | The most common imaging procedure requiring sedation/anesthesia for the pediatric population is magnetic resonance imaging (MRI). However, the optimal anesthetic/sedation plan has not been determined for these procedures. Historically, common medications have included the use of pentobarbital and propofol, but in 2015, publication in the New England Journal of Medicine highlighted the accumulating evidence for the possible neurotoxic effects of these types of anesthetics in animal models and a collection of epidemiologic studies in humans. Although these initial possibilities have since been proven as less of a concern, in the interim, data has shown that alternative sedative agents, such as dexmedetomidine, may not have the same neurotoxic effect and could possibly even provide neuroprote |
| Who can participate | Inclusion Criteria: * Patients presenting as outpatients, scheduled to receive an anesthetic for MRI of brain, body (spine, chest, abdomen, and/or pelvis) and/or extremity (arm and/or leg). * Patients must be a candidate for the sedation technique described in this study with a natural airway. This decision will be made by a staff member of the Department of Anesthesiology. * Between 1 and 12 years of age. * ASA status I, II, or III Exclusion Criteria: * Inpatient at BCH * Diagnosis of a difficult airway, severe obstructive sleep apnea that is not compatible with spontaneous ventilation in a supine position, or requires an oral airway. * Congenital heart disease or history of dysrhythmia. * Taking digoxin or beta-blocker * Anxiolytic medication is ordered before the MRI (e.g., midazolam or |
| Ages | 1 Year to 12 Years |
| Sex | All |
| Lead sponsor | Boston Children's Hospital |
| Locations | Boston, Massachusetts, United States |
| Start date | 2026-06 |
| NCT ID | NCT07369128 |
| Official listing | https://clinicaltrials.gov/study/NCT07369128 |