prTMS as an Intervention for Bradykinesia in Parkinson's Disease
This study investigates the use of patterned repetitive transcranial magnetic stimulation (prTMS) as an intervention for bradykinesia in Parkinson's Disease (PD). More specifically, the study aims to determine whether prTMS over the supplementary motor area (SMA) can reduce severity of bradykinesia in PD patients. This
| Condition(s) | Bradykinesia, Parkinson Disease |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This study investigates the use of patterned repetitive transcranial magnetic stimulation (prTMS) as an intervention for bradykinesia in Parkinson's Disease (PD). More specifically, the study aims to determine whether prTMS over the supplementary motor area (SMA) can reduce severity of bradykinesia in PD patients. This approach may open for more targeted and effective treatment of bradykinesia in PD. |
| Who can participate | Inclusion Criteria: Above 18 years of age. Clinically established or probable Parkinson's Disease (PD), according to the Movement Disorder Society. Clinical Diagnostic Criteria for PD. Stable antiparkinsonian medicine for at least four weeks. Signed informed consent. Exclusion Criteria: Psychiatric disorders. Current use of antipsychotic medication, Donepezil, or GABAergic agents (e.g., pregabalin, gabapentin). Frequent benzodiazepine or opioid use defined as more than once per week on a regular basis. History of neurological disease other than PD. Past or present mental illness. History of epilepsy/conditions associated with increased risk of seizure induction through transcranial magnetic stimulation (TMS). Close relatives suffering from epilepsy/conditions associated with increased risk |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Lead sponsor | Danish Research Centre for Magnetic Resonance |
| Locations | Hvidovre, Denmark |
| Start date | 2025-12-16 |
| NCT ID | NCT07397377 |
| Official listing | https://clinicaltrials.gov/study/NCT07397377 |