Radiomics Compared With Conventional Response Criteria for Predicting Progression of Desmo
Desmoid tumors (DT) are uncommon tumors that arise from musculoaponeurotic structures. Despite benign, they can cause pain and disability due to their tendency to be locally aggressive. Cryoablation, a technique used in interventional radiology, has gained popularity in recent years as a treatment option for sporadic D
| Condition(s) | Desmoid |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Desmoid tumors (DT) are uncommon tumors that arise from musculoaponeurotic structures. Despite benign, they can cause pain and disability due to their tendency to be locally aggressive. Cryoablation, a technique used in interventional radiology, has gained popularity in recent years as a treatment option for sporadic DT. This involves repeated cycles of freezing, leading to cell death. Recent studies showed that percutaneous image-guided cryoablation appears to be safe and effective for local control for patients with extra-abdominal desmoid tumors.Although changes in the heterogeneity of tumors are commonly known, they are often ignored in response criteria that only evaluate tumor size in a single dimension, such as Response Evaluation Criteria in Solid Tumors (RECIST 1.1). Nevertheless, |
| Who can participate | Inclusion Criteria: * desmoid tumor treated at Rizzoli Orthopaedic Institute with cryoablation * baseline MRI * clinical and radiologic follow-up until disease progression or the start of a new line of treatment performed every 3 months, with a minimum of 6 months follow-up Exclusion Criteria: \- not meeting inclusion criteria |
| Sex | All |
| Lead sponsor | Istituto Ortopedico Rizzoli |
| Locations | Bologna, Italy |
| Start date | 2024-02-20 |
| NCT ID | NCT06224283 |
| Official listing | https://clinicaltrials.gov/study/NCT06224283 |