Reconstruction in Extended MArgin Cancer Surgery
Advanced pelvic cancers are uncommon, with treatment being challenging. Around 4000 patients every year need treatment in the UK. Cancers can involve multiple organs and often need radiotherapy and chemotherapy before surgery. Surgery usually requires removal of multiple pelvic organs, including muscles, bone, and skin
| Condition(s) | Surgery--Complications, Pelvic Cancer, Abdominal Cancer, Quality of Life |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Advanced pelvic cancers are uncommon, with treatment being challenging. Around 4000 patients every year need treatment in the UK. Cancers can involve multiple organs and often need radiotherapy and chemotherapy before surgery. Surgery usually requires removal of multiple pelvic organs, including muscles, bone, and skin around the anus (the perineum). This can lead to complications relating to both the empty pelvis syndrome and closure of the perineal defect. Reconstruction is challenging, with frequently occurring complications, reducing speed of recovery and quality of life. This study investigates complication frequency, quality of life and expenses following different reconstruction techniques. The investigators hope to improve patient and doctor decision-making in this area and find th |
| Who can participate | Inclusion Criteria: * Male and female patients aged 18 or older * Patients that have undergone pelvic exenteration or abdominoperineal excision at participating sites, at any time, that have complete data (work package 1 - Colorectal Surgery Database) * Patients undergoing pelvic exenteration or abdominoperineal excision at participating sites (work package 2 - prospective study) * Patients that have already had pelvic exenteration or abdominoperineal resection that can speak English (work package 3 - mixed-methods study) Exclusion Criteria: * Patients eligible for, but that are unfit, decline or are not offered abdominoperineal excision or pelvic exenteration surgery * Patients that undergo surgery by an intersphincteric abdominoperineal resection approach * Patients that are unable to co |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | University Hospital Southampton NHS Foundation Trust |
| Locations | Southampton, Hampshire, United Kingdom; Salisbury, Wiltshire, United Kingdom; Basingstoke, United Kingdom; Brighton, United Kingdom; Cornwell, United Kingdom; Dorchester, United Kingdom (+12 more sites) |
| Start date | 2022-05-17 |
| NCT ID | NCT05219058 |
| Official listing | https://clinicaltrials.gov/study/NCT05219058 |