Relationship Between Circulating Sclerostin and Bone Lesions in Patients With Mastocytosis
Mastocytosis is very rare and highly heterogeneous group of disorders, characterized by the accumulation of clonal mast cells which can infiltrate several organs and tissues. Bones are the most frequent localization of systemic mastocytosis. The aim of our research was to explain the potential role of sclerostin in the
| Condition(s) | Mastocytosis, Bones |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Mastocytosis is very rare and highly heterogeneous group of disorders, characterized by the accumulation of clonal mast cells which can infiltrate several organs and tissues. Bones are the most frequent localization of systemic mastocytosis. The aim of our research was to explain the potential role of sclerostin in the pathogenesis of bone disease in mastocytosis. |
| Who can participate | Inclusion Criteria: * Age \> 18 years * Mastocytosis defined according to WHO criteria * Known KIT mutation status Exclusion Criteria: * History of organ transplant * Inability to give informed consent * Pregnancy, Breastfeeding * Vulnerable Patient, defined as: patient with another uncontrolled severe disease; patient under juridical protection |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Medical University of Lublin |
| Locations | Lublin, Lublin Voivodeship, Poland |
| Start date | 2019-09-01 |
| NCT ID | NCT06440148 |
| Official listing | https://clinicaltrials.gov/study/NCT06440148 |