Remifentanil Effect on Burst Suppression Ratio
The goal of this clinical trial is to determine whether remifentanil has a facilitating effect on the generation of burst suppression by propofol in adult patients (18-60 years) candidates for elective surgery who require remifentanil and American Society of Anesthesiology (ASA) classification I or II. The main questio
| Condition(s) | Anesthesia, Intravenous, Electroencephalography, Burst Suppression |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The goal of this clinical trial is to determine whether remifentanil has a facilitating effect on the generation of burst suppression by propofol in adult patients (18-60 years) candidates for elective surgery who require remifentanil and American Society of Anesthesiology (ASA) classification I or II. The main question it aims to answer are: • To determine whether remifentanil has a facilitating effect on the generation of burst suppression by propofol. Participants will undergo general anesthesia with remifentanil and propofol sequentially. After loss of consciousness, remifentanil will be adjusted to a medium or high concentration randomly and it will be determined at what concentration of propofol the burst suppressions are generated. Then, the concentrations of propofol that generate |
| Who can participate | Inclusion Criteria: * American Society of Anesthesiology I or II * Elective surgery of low or intermediate risk Exclusion Criteria: * Neurological disease * Psychiatric disease * Use of psychoactive drugs or opioids * Altered basal state of consciousness * Allergy to propofol * Body mass index \> 35 kg/m2 * Pre-existing renal, cardiac and/or hepatic dysfunction * Patient's refusal to participate |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Lead sponsor | University of Chile |
| Locations | Santiago, RM, Chile; Santiago, RM, Chile |
| Start date | 2024-03-01 |
| NCT ID | NCT06237101 |
| Official listing | https://clinicaltrials.gov/study/NCT06237101 |