Remote Ischemic Preconditioning and Postoperative Neuronal Injury
The SHIELD trial is a single-center, randomized, controlled, parallel-group, single-blinded clinical trial investigating whether performing RIPC one day before surgery-compared to not performing RIPC-reduces postoperative neuronal injury, as reflected by the maximum serum NfL concentration within the first 2 postoperat
| Condition(s) | Postoperative Neuronal Injury |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The SHIELD trial is a single-center, randomized, controlled, parallel-group, single-blinded clinical trial investigating whether performing RIPC one day before surgery-compared to not performing RIPC-reduces postoperative neuronal injury, as reflected by the maximum serum NfL concentration within the first 2 postoperative days, in non-cardiac surgery patients at risk for postoperative delirium. |
| Who can participate | Inclusion criteria: * patients (≥50 years) scheduled for elective non-cardiac surgery with general anesthesia * patients at risk for postoperative delirium, defined as the presence of ≥2 of the following established risk factors: age ≥65 years, American Society of Anesthesiologists physical status classification of ≥III, Charlson Comorbidity, planned surgical duration \>180 minutes, polypharmacy (regular intake of more than five medications), symptoms of depression (Patient Health Questionnaire-9 ≥10 points) Exclusion criteria: * patients in whom RIPC cannot be safely applied due to relevant peripheral arterial disease (defined as Fontaine stage ≥II), lymphedema, recent upper-arm surgery, trauma, or skin lesions at the arm * patients with acute coronary syndrome (within the past month) * p |
| Ages | 50 Years |
| Sex | All |
| Lead sponsor | University of Hamburg-Eppendorf |
| Locations | Hamburg, Free and Hanseatic City of Hamburg, Germany |
| Start date | 2026-03-02 |
| NCT ID | NCT07420153 |
| Official listing | https://clinicaltrials.gov/study/NCT07420153 |