Retrospective Observational Evaluation of the Bone Mineral Density Outcome in Young Women
The study aims to evaluate the outcomes of different estrogen therapy regimens in patients with amenorrhea who face prolonged periods of hypoestrogenism. The primary objective is to compare the outcomes on bone mass of different therapeutic regimens and identify more favorable. For this purpose, densitometry parameters
| Condition(s) | Amenorrhea |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The study aims to evaluate the outcomes of different estrogen therapy regimens in patients with amenorrhea who face prolonged periods of hypoestrogenism. The primary objective is to compare the outcomes on bone mass of different therapeutic regimens and identify more favorable. For this purpose, densitometry parameters such as BMD, T-score and Z-score at the level of the lumbar spine, femur and entire skeleton will be considered, comparing a bone densitometry (DXA technique, Dual X-ray Absorptiometry) Baseline with one carried out after at least one year of therapy. The secondary objective of the study is to assess other systemic/metabolic implications of the different therapies. |
| Who can participate | Inclusion criteria: * Patients who have presented themselves to the O.U. of Gynecology and Human Reproduction Pathophysiology in the period from 2011 to 2020 with amenorrhea over 6 months, and aged between 15 and 39 years at the time of the visit. * Patients who have reached the age of 18 at the time of surgery. * Patients for whom informed consent has been obtained. Exclusion criteria: No exclusion criteria are provided. |
| Ages | 15 Years to 39 Years |
| Sex | Female |
| Lead sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna |
| Locations | Bologna, Italy |
| Start date | 2020-11-09 |
| NCT ID | NCT07015476 |
| Official listing | https://clinicaltrials.gov/study/NCT07015476 |