Sarcopenia and Related Factors in Patients With Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic disease affecting the central nervous system, exhibiting autoimmune and neurodegenerative properties. Neurological deficits, mobility limitations, and decreased muscle strength are commonly observed in MS patients as the disease progresses. The literature indicates that low physical
| Condition(s) | Multiple Sclerosis, Sarcopenia |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Multiple Sclerosis (MS) is a chronic disease affecting the central nervous system, exhibiting autoimmune and neurodegenerative properties. Neurological deficits, mobility limitations, and decreased muscle strength are commonly observed in MS patients as the disease progresses. The literature indicates that low physical activity levels and neurological deficits in individuals with MS can lead to decreased muscle mass and functional losses. Sarcopenia is a condition characterized by decreased skeletal muscle mass and strength associated with aging and chronic diseases, and studies on the prevalence of sarcopenia in MS patients are limited. Recent studies have revealed a high prevalence of sarcopenia in MS patients, which can have negative effects on physical performance, quality of life, and |
| Who can participate | Inclusion Criteria: * Being 18 years of age or older, * Having been diagnosed with Multiple Sclerosis (confirmed by a neurologist), * Being in a stable phase of the disease (having not had an attack in the last 3 months), * Having preserved walking ability (EDSS score ≤6.5), * Being able to give informed consent to participate in the study. Exclusion Criteria: * Having another neuromuscular disease. * Having developed significant muscle loss within the last 6 months due to use of corticosteroids or immunosuppressive therapy. * Having systemic diseases that can cause muscle loss, such as cancer, rheumatic diseases, or severe metabolic disorders. * Having undergone major surgery or a history of serious trauma within the last 3 months. * Being pregnant or breastfeeding. |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Selcuk University |
| Locations | Konya, Selcuklu, Turkey (Türkiye) |
| Start date | 2025-06-01 |
| NCT ID | NCT07116070 |
| Official listing | https://clinicaltrials.gov/study/NCT07116070 |