SAS 1: Develop Ocular Disease (OSD) Diagnostic, Algorithms, and Management Protocols for C
Patient: Tear film issues resulting in poor visual outcomes are a major cause of dissatisfaction after cataract surgery. There is no universal best preoperative algorithm for managing the ocular surface prior to surgery. Industry: Recent advances in tear/cornea imaging and refractive cataract surgery such as multifocal
| Condition(s) | Dry Eye |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Patient: Tear film issues resulting in poor visual outcomes are a major cause of dissatisfaction after cataract surgery. There is no universal best preoperative algorithm for managing the ocular surface prior to surgery. Industry: Recent advances in tear/cornea imaging and refractive cataract surgery such as multifocal intraocular lenses will be advantageous to patients only if tear film issues can be addressed. Society: Cataract surgery is the most common ophthalmic surgery done in Singapore and worldwide. Improving vision by attending to tear film problems improves quality of life. |
| Who can participate | Inclusion Criteria: * Inclusion criteria for dry eye (participant must meet at least 1 of the inclusion criteria below): 1. Symptomatic for dry eye based on DEQ5 (\>6) and \[either TBUT less than 5 s or staining \>grade 1 in any zone of the cornea\] 2. Either use of diquasfosol, cyclosporine eyedrops or tacrolimus eyedrops for dry eye disease in the last 2 weeks (and previously started for more than 2 months), OR current and visible lower punctal plugs in at least one eye Inclusion criteria to fulfil all for controls (patients w/o dry eye): 1. DEQ5 \<=6. 2. Staining \< grade 1 in at least one corneal zone. 3. Not using diquasfosol, cyclosporine, tacrolimus in last 2 months. 4. No visible punctal plugs. Exclusion Criteria: * If there is another ocular condition which affects vision as much |
| Ages | 21 Years to 99 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Louis Tong |
| Locations | Singapore, Singapore |
| Start date | 2025-06-27 |
| NCT ID | NCT07323264 |
| Official listing | https://clinicaltrials.gov/study/NCT07323264 |