Secondary Sclerosis Cholangitis Prospective
SC-CIP is increasing in patients after critical illness. Pathogenesis is still largely unclear. Gut microbiome composition, gut permeability, bacterial translocation, inflammation and/or genetic variants contribute to the pathogenesis The aim of this project is to study gut microbiome composition, gut permeability, bac
| Condition(s) | Secondary Sclerosis Cholangitis in Critically Ill Patients |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | SC-CIP is increasing in patients after critical illness. Pathogenesis is still largely unclear. Gut microbiome composition, gut permeability, bacterial translocation, inflammation and/or genetic variants contribute to the pathogenesis The aim of this project is to study gut microbiome composition, gut permeability, bacterial translocation, inflammation, bile acid composition and genetic polymorphisms by conducting a prospective cohort study in patients with a high risk to develop SC-CIP. |
| Who can participate | Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study OR "surrogate consent" by the institutional review board. * Age above 18 years * Mechanical ventilation or extracorporeal membrane oxygenation \>/= 5 days Exclusion Criteria: * Primary or secondary sclerosing cholangitis diagnosed before current ICU admission |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Medical University of Graz |
| Locations | Graz, Austria |
| Start date | 2018-07-20 |
| NCT ID | NCT03566797 |
| Official listing | https://clinicaltrials.gov/study/NCT03566797 |