Septic Shock-induced Immunosuppression
Septic syndromes are a major although largely under-recognized health care problem and represent the first cause of mortality in intensive care units (ICU). While it has long been known that sepsis deeply perturbs immune homeostasis by inducing a tremendous systemic inflammatory response, novel findings indicate that s
| Condition(s) | Septic Shock |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Septic syndromes are a major although largely under-recognized health care problem and represent the first cause of mortality in intensive care units (ICU). While it has long been known that sepsis deeply perturbs immune homeostasis by inducing a tremendous systemic inflammatory response, novel findings indicate that sepsis indeed initiates a more complex immune response that varies over time, with the concomitant occurrence of both pro- and anti-inflammatory mechanisms. As a resultant, after a short pro-inflammatory phase, septic patients enter a stage of protracted immunosuppression. This is illustrated in those patients by reactivation of dormant viruses (cytomegalovirus (CMV) or Herpes Simplex Virus (HSV)) or infections due to pathogens, including fungi, which are normally pathogenic s |
| Who can participate | Inclusion Criteria: * Age over 18 years * Patient admitted to ICU * Diagnosis of septic shock within less than 48h at time of screening defined by : * Presence of a microbiologically diagnosed or suspected infection * Initiation of a vasopressive treatment to maintain mean arterial blood pressure ≥ 65 mm Hg initiated during the first 48h after ICU admission * Presence of an hyperlactatemia \> 2 mmol/L (18 mg/dL) during the 24h before or after initiation of vasopressive treatment despite adequate volemic reanimation (30 ml/kg) * Blood sample at D3/D4 available (lab working days) * Non opposition to study participation obtained from patient or next of kin Exclusion Criteria: * Pregnant or breastfeeding woman * Patient with no social security insurance, with restricted liberty or under legal |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Hospices Civils de Lyon |
| Locations | Lyon, France |
| Start date | 2019-10-21 |
| NCT ID | NCT04067674 |
| Official listing | https://clinicaltrials.gov/study/NCT04067674 |