SNRK & Vascular Endothelial Aging
Cardiovascular diseases pose a serious threat to public health, and their prevalence is on the rise year by year. Vascular aging is an independent risk factor for cardiovascular diseases, and endothelial cell senescence is an early event in vascular aging. Its occurrence can lead to endothelium-dependent vasodilation d
| Condition(s) | Vascular Aging |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Cardiovascular diseases pose a serious threat to public health, and their prevalence is on the rise year by year. Vascular aging is an independent risk factor for cardiovascular diseases, and endothelial cell senescence is an early event in vascular aging. Its occurrence can lead to endothelium-dependent vasodilation dysfunction, reduced vascular permeability, and the release of the senescence-associated secretory phenotype (SASP). These vascular pathological changes further damage the vascular media, leading to vascular remodeling and reduced compliance, accelerating the progression of atherosclerosis, and ultimately resulting in cardiovascular diseases such as coronary heart disease and hypertension. Recent research of the investigators has revealed that SNRK, a new member of the AMPK fa |
| Who can participate | Inclusion Criteria: 1. Aged 18-80 years, with the capacity to make decisions independently or represented by an authorized legal guardian; 2. Able to provide complete personal information, medical history, and lifestyle history (e.g., smoking and alcohol consumption history); 3. No history of severe cardiovascular disease, and deemed eligible for inclusion by a physician. Exclusion Criteria: 1. Women who are pregnant or may become pregnant; 2. Patients with a history of neurological disorders, tumors, severe cardiovascular or pulmonary disease, liver failure, kidney failure, or blood disorders; 3. Patients who have undergone carotid stenting, carotid endarterectomy, or other similar procedures, or who have unilateral carotid artery occlusion due to any cause; 4. Patients who have participa |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Tianjin Medical University |
| Locations | Tianjin, Tianjin Municipality, China |
| Start date | 2026-05-01 |
| NCT ID | NCT07591337 |
| Official listing | https://clinicaltrials.gov/study/NCT07591337 |