Stanford Pragmatic Effectiveness Comparison
Chronic pain is a major healthcare problem with an annual cost of above $600 billion. The quality of data available for treatments of chronic pain is not optimal. Generalizability of explanatory randomized controlled trial data is problematic as these trials exclude up to 90% of patients: leaving out real-world patient
| Condition(s) | Chronic Pain |
|---|---|
| Status | Recruiting |
| Phase | Phase 4 |
| Study type | Interventional |
| Summary | Chronic pain is a major healthcare problem with an annual cost of above $600 billion. The quality of data available for treatments of chronic pain is not optimal. Generalizability of explanatory randomized controlled trial data is problematic as these trials exclude up to 90% of patients: leaving out real-world patients with serious medical and psychological comorbidities. Pragmatic trials embedded in patient care compare effectiveness of currently used treatments in real-world application leading to findings that generalize to broader range of patients. The changes in clinical practice and workflow necessary to integrate this type of research within patient care present pragmatic challenges. In this research, the overall objective is to overcome these challenges using an open-source learn |
| Who can participate | Inclusion Criteria: * Age of 18 years old or above * Persistent pain for more than 3 months * Candidate for treatment by anti-convulsants or anti-depressants based on treating pain provider * Equipoise between anti-convulsants and anti-depressants according to the treating pain provider Exclusion Criteria: * Contraindication to taking anti-convulsants or anti-depressants: this exclusion is based on the judgement of the treating pain provider; e.g. if the patient is on a large dose of serotonin specific reuptake inhibitor (SSRI) anti-depressant, it will stop the physician from considering any other anti-depressants; thus, excluding the patient * Patient refusal |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Stanford University |
| Locations | Redwood City, California, United States |
| Start date | 2022-04-12 |
| NCT ID | NCT04441034 |
| Official listing | https://clinicaltrials.gov/study/NCT04441034 |