Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplant
The purpose of this study is to find a safe and tolerable way to improve engraftment after transplant. Research studies have shown that adding nicotinamide riboside to donor cells has the potential to increase blood stem cell numbers and potentially decrease the time to engraftment. Also, nicotinamide riboside, TRU NIA
| Condition(s) | Allogeneic Hematopoietic Cell Transplantation |
|---|---|
| Status | Recruiting |
| Phase | EARLY_Phase 1 |
| Study type | Interventional |
| Summary | The purpose of this study is to find a safe and tolerable way to improve engraftment after transplant. Research studies have shown that adding nicotinamide riboside to donor cells has the potential to increase blood stem cell numbers and potentially decrease the time to engraftment. Also, nicotinamide riboside, TRU NIAGEN (the study drug) is a type of vitamin B supplement that the general public can get without a prescription and is well tolerated. |
| Who can participate | Inclusion Criteria: * All disease indications for allogeneic hematopoietic cell transplantation except for myelofibrosis. * Subject must meet program eligibility criteria\* for myeloablative conditioning alloHCT and plan to undergo myeloablative conditioning. * HLA-identical related donor or unrelated human donor source with bone marrow graft. * Subjects must provide a written informed consent. Exclusion Criteria: * History of allergy or intolerance to NR precursor compounds, including niacin or nicotinamide * Pregnant or breastfeeding women are excluded from this study since allogeneic HCT is a strict contraindication. * Subjects with uncontrolled intercurrent illness or psychiatric illness/social situations that would limit compliance with study requirements. |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Case Comprehensive Cancer Center |
| Locations | Cleveland, Ohio, United States |
| Start date | 2020-05-19 |
| NCT ID | NCT04332341 |
| Official listing | https://clinicaltrials.gov/study/NCT04332341 |