STUDY OF THE DOUBLE POLYMORPHISM (THR 555ILE) AND (GLU568PRO) OF THE CORIN GENE AS A RISK
Cardiovascular disease (CVD) mortality is the leading cause of death in high-income countries (particularly the United States), accounting for 23.1% of all deaths It has been established over several decades that hypertension disproportionately affects African Americans, compared with Americans of European descent:Hype
| Condition(s) | High Blood Pressure |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Cardiovascular disease (CVD) mortality is the leading cause of death in high-income countries (particularly the United States), accounting for 23.1% of all deaths It has been established over several decades that hypertension disproportionately affects African Americans, compared with Americans of European descent:Hypertension occurs more often, at an earlier age , with greater severity , and is associated with an approximately 3-fold higher probability of death .There is also poorer control of hypertension despit e similar treatment In African Americans, CVD morbidity and mortality are compounded by the higher prevalence of T2DM, obesity, CKD, stroke, and heart failure . Despite advances in the identification of risk factors and the availability of effective treatment in hypertension, CVD |
| Who can participate | Inclusion Criteria: Case inclusion criteria * Persons affiliated with or benefiting from a social security plan; * Over 18 years of age; * Considering themselves to be of Afro-Caribbean descent; * Having given their free, informed, written and signed consent (at the latest on the day of inclusion and before any examination required by the research); * Treated for hypertension or presenting with hypertension according to recommendations: elevated blood pressure (BP), including systolic blood pressure (SBP) ≥140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg measured in the physician's office and confirmed over several visits on the day of inclusion or diagnosis made by ABPM or self-measurement. Control inclusion criteria: * Individuals affiliated with or benefiting from a social secur |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Centre Hospitalier Universitaire de la Guadeloupe |
| Locations | Petit-Bourg, Guadeloupe; Petit-Canal, Guadeloupe |
| Start date | 2025-01-16 |
| NCT ID | NCT07330804 |
| Official listing | https://clinicaltrials.gov/study/NCT07330804 |