Study of the Nasal Intracellular Reservoir of Staphylococcus Aureus in Patients With S. Au
Staphylococcus aureus bacteremia is a serious infection associated with a high mortality rate (with or without associated infective endocarditis (IE)), long hospital stays and multiple complications, due to the terrain in which it occurs and its secondary localization. They may be community-acquired or healthcare-assoc
| Condition(s) | Bacteria Infection Mechanism |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Staphylococcus aureus bacteremia is a serious infection associated with a high mortality rate (with or without associated infective endocarditis (IE)), long hospital stays and multiple complications, due to the terrain in which it occurs and its secondary localization. They may be community-acquired or healthcare-associated infections. Being a carrier of S. aureus is a known risk factor for S. aureus bacteremia. Although several mucosal sites of carriage have been described, screening for carriage is most often carried out at the nasal level, both for reasons of simplicity and because it is the predominant site of carriage of this bacterium. However, S. aureus carriage is a frequent occurrence, affecting around 1/3 of the general population. |
| Who can participate | Inclusion Criteria: * Bacteremia * Patient affiliated or entitled to a social security plan * Patient who has signed a consent form to participate in the study. Exclusion Criteria: * Antibiotic therapy in place for more than 5 days at the time of inclusion * Nasal decolonization of S. aureus within 12 months * Pregnant or breast-feeding women * Patients under guardianship * Polymicrobial bacteremia including S. aureus |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Centre Hospitalier Universitaire de Saint Etienne |
| Locations | Saint-Etienne, France |
| Start date | 2024-09-02 |
| NCT ID | NCT06594250 |
| Official listing | https://clinicaltrials.gov/study/NCT06594250 |