Subcortical Arousal in Perceptual Awareness
The study consists of prospective enrollment of healthy participants and patients with epilepsy, as well as analysis of an existing data set. Healthy participants will be studied with fMRI, eye metrics and behavioral testing at Yale. Patients will be studied with intracranial thalamic and cortical recording and stimula
| Condition(s) | Epilepsy |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The study consists of prospective enrollment of healthy participants and patients with epilepsy, as well as analysis of an existing data set. Healthy participants will be studied with fMRI, eye metrics and behavioral testing at Yale. Patients will be studied with intracranial thalamic and cortical recording and stimulation, eye metrics and behavioral testing. |
| Who can participate | A. The following are the inclusion/exclusion criteria for healthy participants age 18 years and up (Aim 1 and 2): Inclusion: (1) normal vision with or without the use of corrective lenses; (2) normal hearing not needing an assistive hearing device. Exclusion: (1) past history of diagnosis of a psychiatric or neurologic disease; (2) current psychiatric or neurologic disease; (3) requires hard contact lenses or glasses to maintain normal vision (prevents accurate pupil and eye gaze measurements); (4) pregnant or nonremovable ferrous metal objects inside or on the body (prevents MRI). B. The following are the inclusion/exclusion criteria for epilepsy patients with thalamic electrodes age 13 years and up (Aim 3A): Inclusion: (1) normal vision with or without the use of corrective lenses Exclus |
| Ages | 13 Years |
| Sex | All |
| Lead sponsor | Yale University |
| Locations | New Haven, Connecticut, United States; Kansas City, Kansas, United States; Boston, Massachusetts, United States; Rochester, Minnesota, United States; Lebanon, New Hampshire, United States; Pittsburgh, Pennsylvania, United States (+2 more sites) |
| Start date | 2025-10-13 |
| NCT ID | NCT06934356 |
| Official listing | https://clinicaltrials.gov/study/NCT06934356 |