Targeted Optical Biopsy for Local Rectal Scars in Rectal Cancer Patients After Neoadjuvant
Currently, low concordance (36%) is found between clinical complete response and pathologic complete response in patients with rectal cancer after neoadjuvant chemoradiotherapy. Probe-based confocal laser endoscopy (pCLE) provides a promising targeted optical biopsy to evaluate the response to neoadjuvant chemoradiothe
| Condition(s) | Rectal Cancer |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Currently, low concordance (36%) is found between clinical complete response and pathologic complete response in patients with rectal cancer after neoadjuvant chemoradiotherapy. Probe-based confocal laser endoscopy (pCLE) provides a promising targeted optical biopsy to evaluate the response to neoadjuvant chemoradiotherapy. The aim of this study is to investigate whether pCLE-targeted optical biopsy can improve the accuracy of preoperative endoscopic biopsy for local rectal scars in rectal cancer patients after neoadjuvant chemoradiotherapy. |
| Who can participate | Inclusion Criteria: 1. Age from over 18 to under 80 years 2. American Society of Anesthesiology(ASA) score class I,II,or III 3. Locally advanced rectal cancer 4. Patient has completed standard neoadjuvant therapy 5. Expected surgical resection 6. Written informed consent Exclusion Criteria: 1. Pregnant or lactating women 2. Acute renal insufficiency or stage II to IV chronic renal insufficiency 3. Patients with allergic constitution |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Lead sponsor | Nanfang Hospital, Southern Medical University |
| Locations | Guangzhou, Guangdong, China |
| Start date | 2021-11-04 |
| NCT ID | NCT05316103 |
| Official listing | https://clinicaltrials.gov/study/NCT05316103 |