Targeted Transcranial Magnetic Stimulation to Improve Hippocampal-dependent Declarative Me
This is a pilot study of non-invasive transcranial magnetic stimulation (TMS) to improve memory in healthy adults. It will also examine treating memory deficits in older adults with amnestic mild cognitive impairment (aMCI), a condition that frequently precedes Alzheimer's disease (AD). The study will test whether a fo
| Condition(s) | Mild Cognitive Impairment, Memory Loss |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This is a pilot study of non-invasive transcranial magnetic stimulation (TMS) to improve memory in healthy adults. It will also examine treating memory deficits in older adults with amnestic mild cognitive impairment (aMCI), a condition that frequently precedes Alzheimer's disease (AD). The study will test whether a form of non-invasive brain stimulation repetitive transcranial magnetic stimulation (rTMS) can improve memory abilities in healthy young adults, healthy older adults, and older adults with aMCI by retuning memory-related brain networks. This study is a key first step which will support the long-term goal of treating memory deficits in neurological patients. It is expected that rTMS will improve memory abilities in all participants, and that the improvements in memory will be at |
| Who can participate | The investigators anticipate enrolling 48 subjects total: * 16 healthy young adults (age 19-35) * 16 healthy older adults (demographically matched to aMCI group for age, sex, and educational attainment) * 16 older adults diagnosed with amnestic mild cognitive impairment (aMCI) Inclusion Criteria: 1. Adults 19 years of age and older 2. Healthy adults without history of psychiatric or neurological disease OR previous diagnosis of amnestic MCI 3. Must be able to provide informed consent 4. Must have the ability to comply with basic instructions and have the ability to sit comfortably still for TMS, neuroimaging, and other study procedures. 5. Right-handed based on self-report (pre-screening) and evaluation with a standard test. Exclusion Criteria: 1. Individuals who have ferrous metal implant |
| Ages | 19 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Nebraska |
| Locations | Omaha, Nebraska, United States |
| Start date | 2019-01-01 |
| NCT ID | NCT03574207 |
| Official listing | https://clinicaltrials.gov/study/NCT03574207 |