Testosterone Levels and Cutibacterium
Phase 1: In 51 patients undergoing shoulder arthroplasties, total serum testosterone, free testosterone and sex hormone binding globulin levels obtained in the clinic before surgery were correlated with the levels of Cutibacterium on the skin in clinic, in the operating room prior to surgery, and in the skin incision.
| Condition(s) | Arthroplasty, Replacement, Shoulder |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Phase 1: In 51 patients undergoing shoulder arthroplasties, total serum testosterone, free testosterone and sex hormone binding globulin levels obtained in the clinic before surgery were correlated with the levels of Cutibacterium on the skin in clinic, in the operating room prior to surgery, and in the skin incision. Phase 2: The investigators wish to determine if preoperative serum testosterone levels are associated with risk for shoulder PJI (periprosthetic joint infection) in patients undergoing primary shoulder arthroplasty. Also to determine if preoperative serum testosterone levels are predictive of bacterial load of deep tissue cultures taken at the time of revision shoulder arthroplasty in patients undergoing primary shoulder arthroplasty. |
| Who can participate | Phase 1 Inclusion Criteria: * Patients having elective shoulder arthroplasty Phase 1 Exclusion Criteria: * history of shoulder septic arthritis * antibiotic use within 3 months prior to surgery * recent treatment for acne * Lacked fluency in English Phase 2 Inclusion Criteria: * Patients having elective shoulder arthroplasty Phase 2 Exclusion Criteria: * Lacked fluency in English |
| Ages | 18 Years to 89 Years |
| Sex | All |
| Lead sponsor | University of Washington |
| Locations | Seattle, Washington, United States |
| Start date | 2020-07-01 |
| NCT ID | NCT05030220 |
| Official listing | https://clinicaltrials.gov/study/NCT05030220 |