The EEG Study Under Sevoflurane Anesthesia in Children
Sevoflurane is one of the most commonly used volatile anesthetics in children because of its rapid induction, recovery and recovery properties. Clinical studies using noninvasive brain monitoring have shown that general anesthetics and hypnotics generate electroencephalogram (EEG) oscillations in specific spatial tissu
| Condition(s) | Electroencephalography, Sevoflurane, Child Neglect |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Sevoflurane is one of the most commonly used volatile anesthetics in children because of its rapid induction, recovery and recovery properties. Clinical studies using noninvasive brain monitoring have shown that general anesthetics and hypnotics generate electroencephalogram (EEG) oscillations in specific spatial tissues that are fundamentally related to the structure and function of neural circuits. Slow-wave-delta (0.1-4 Hz) oscillations were present in children of all ages, and the advantage of frontal α-wave oscillations appeared at approximately 6 months, began to be consistent at 10 months, and persisted at older ages. Another study, which analyzed EEG under sevoflurane general anesthesia in children aged 0-6 months, found that Theta and alpha wave power decreased with a decrease in |
| Who can participate | Inclusion Criteria: 1. aged 1 days#6 years#; 2. with American Society of Anesthesiologists (ASA) physical status I or II#; 3. children requiring general anesthesia under sevoflurane; 4. parents or legal guardians of children who volunteered to participate in the trial; And signed the informed consent form. Exclusion Criteria: 1. Congenital malformation or other genetic conditions that are thought to affect brain development ; 2. History of severe heart, brain, liver, kidney and metabolic diseases ; 3. Premature infants (≤32 weeks); 4. Upper respiratory tract infection in the last two weeks. |
| Ages | 1 Day to 6 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Second Affiliated Hospital of Wenzhou Medical University |
| Locations | Wenzhou, Zhejiang, China |
| Start date | 2024-09-04 |
| NCT ID | NCT06580028 |
| Official listing | https://clinicaltrials.gov/study/NCT06580028 |